49. Ed Sheeran
The singer-songwriter, who goes by @teddysphotos on Instagram, has 27.2 million followers.
48. Robert Downey Jr.
The "Ironman" and "Avengers" star, whose handle is @robertdowneyjr, has 27.3 million followers.
47. Leonardo DiCaprio
The actor and producer has 28 million followers to his account, @leonardodicaprio.
46. Snoop Dogg
The rapper and producer, whose handle is @snoopdogg, has 28.6 million Instagram followers.
45. Louis Vuitton Official
The luxury label has 29 million followers to its handle, @louisvuitton. It's one of two brands to crack the top 50.
44. Vanessa Hudgens
The actor and singer, whose handle is @vanessahudgens, has 31.6 million followers.
41. Bruna Marquezine
The Brazilian actress, whose Instagram handle is @brumarquezine, has 33.7 million followers.
40. Marcelo Vieira Jr.
The Brazilian soccer star, who plays for Spanish club Real Madrid, has 34.5 million followers to his account, @marcelotwelve.
39. Zlatan Ibrahimović
The Swedish soccer star, who goes by @iamzlatanibrahimovic on Instagram, has 35.9 million followers. Ibrahimović plays for LA Galaxy.
38. Zac Efron
The "Baywatch" actor, whose handle is @zacefron on Instagram, has 37 million followers.
37. Gareth Bale
The Welsh soccer star, who plays for Spanish club Real Madrid, has 38.1 million followers to his Instagram account, @garethbale11.
36. Shawn Mendes
The Canadian singer-songwriter — and former Vine star — has 39.1 million followers to his Instagram account, @shawnmendes.
35. James Rodríguez
The Colombian soccer star, who currently plays for German club Bayern Munich, has 40.8 million followers to his Instagram account, @jamesrodriguez10.
34. Cara Delevingne
The English model and actor, whose Instagram handle is @caradelevingne, has 41.4 million followers.
33. LeBron James
The professional basketball player, who currently plays for the LA Lakers, has 46.2 million followers to his Instagram account, @kingjames.
30. Emma Watson
The English actor and "Harry Potter" star has 49.5 million followers to her Instagram account, @emmawatson.
29. Vin Diesel
The "Fast and the Furious" star, whose handle is @vindiesel, has 51.5 million followers on Instagram.
28. Drake
The Canadian rapper, producer, and actor — who goes by @champagnepapi on Instagram — has 52.6 million followers.
27. David Beckham
The English former professional soccer player has 53.1 million followers to his Instagram account, @davidbeckham.
26. Justin Timberlake
The singer and actor, whose Instagram handle is @justintimberlake, has 53.2 million followers.
24. Shakira
The Colombian singer-songwriter, whose Instagram handle is @shakira, has 55.8 million followers.
23. Ellen DeGeneres
The TV host and comedian — who goes by @theellenshow on Instagram — has 63.2 million followers.
22. Rihanna
The singer, actor, and entrepreneur — who goes by @badgalriri on Instagram — has 66.6 million followers.
21. Kevin Hart
The actor and comedian — who goes by @kevinhart4real on Instagram — has 67.2 million followers.
20. Demi Lovato
The singer-songwriter and actor — who goes by @ddlovato on Instagram — has 70.8 million followers.
19. Kourtney Kardashian
The reality TV star — who goes by @kourtneykardash on Instagram — has 71.6 million followers.
18. Katy Perry
The singer, whose Instagram handle is @katyperry, has 74.5 million followers on Instagram.
15. Jennifer Lopez
The singer, dancer, and actor — who goes by @jlo on Instagram — has 84.2 million followers.
14. Khloe Kardashian
The reality TV star and entrepreneur has 84.5 million followers to her Instagram account, @khloekardashian.
12. Kendall Jenner
The reality TV star and model has 101 million followers to her Instagram account, @kendalljenner.
11. Justin Bieber
The Canadian singer-songwriter, whose Instagram handle is @justinbieber, has 103 million followers.
10. Lionel Messi
The Argentinian soccer star, who plays for Spanish club FC Barcelona, has 105 million followers to his Instagram account, @leomessi.
9. Neymar
The Brazilian soccer star, who plays for French club Paris Saint-Germain, has 108 million followers to his Instagram account, @neymarjr.
6. Kylie Jenner
The reality TV star and entrepreneur, whose Instagram handle is @kyliejenner, has 122 million followers.
5. Kim Kardashian West
The reality TV star and entrepreneur has 123 million followers to her account, @kimkardashian.
4. Dwayne Johnson
The former pro wrestler and actor — who goes by @therock on Instagram — has 126 million followers.
3. Ariana Grande
The singer and actor has 141 million followers to her Instagram account, @arianagrande.
2. Selena Gomez
The singer and actor has 144 million followers to her Instagram account, @selenagomez.
1. Cristiano Ronaldo
The Portuguese soccer star, who plays for Italian club Juventus, has 149 million followers to his account, @cristiano.
