"I have body dysmorphia. I have a lot of deep insecurities," the 35-year-old actress said.
"We may look at somebody and think, 'That person's so beautiful. Their life must be so easy.' They most likely don't feel that way about themselves," she told the outlet.
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Body dysmorphia is a mental health disorder that affects the way a person thinks about and views their physical selves, Insider's Sarah Fielding reported.
An individual with body dysmorphia often fixates on their perceived physical flaws and compares themselves to others. It's common for those with the disorder to also have depression, obsessive-compulsive disorder, anxiety disorder, and substance misuse.
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According to the Cleveland Clinic, an estimated 5 million to 10 million people in the US have body dysmorphia, though the numbers may be higher since many individuals refrain from receiving an official diagnosis.
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Earlier this year, the "Jennifer's Body" actress opened up about facing mental-health struggles during her adolescence.
"I came into the world really bright and sunny and happy," the Tennessee-born star told CR Fashion Book in September.
She continued, "However, at a certain point, I went through some trauma in childhood and I developed a pretty severe eating disorder and manic depression, which runs in my family, so there was definitely some wrestling with chemical imbalance going on."
As Fox catapulted into the spotlight from her role as love interest Mikaela Banes in the 2007 film "Transformers," she grew frustrated by the widely held assumption that she was shallow and lacked intellect.
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"I had always known that I was smart, so it was weird to have that one thing taken away from me now that I'm famous," Fox said. "When I was growing up, being smart was the only thing that I felt was a strong suit for me. I never resonated with being pretty or being popular, I was none of those things."
She went on: "All of these other reasons that people recognize me, all of which I don't resonate with or believe, and then to have the one thing that I do believe about myself be taken away, has been very challenging."
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