Microbiome testing startup uBiome is the fourth largest startup to shut down in 2019. Here are the top 11 startups that have died so far this year.

uBiome; Yutong Yuan/Business Insider

UBiome founders and former co-CEOs Zac Apte and Jessica Richman

• Microbiome testing startup uBiome announced Wednesday it was filing for bankruptcy after months of controversy and federal investigations into its testing procedures and billing practices.
• According to data from Pitchbook, uBiome is the fourth-largest startup to go under so far in 2019.
• Consumer robotics maker Anki was the highest valued startup to go under and announced it was shutting down in May.
• Here are the top 11 startups that went bust so far in 2019.
• Visit Business Insider's homepage for more stories.

A shadow is falling over Silicon Valley, and some of its most promising startups are crumbling under the pressure.

Just this Wednesday, high flying microbiome startup uBiome announced it was filing for bankruptcy after months of controversy and federal investigations into its testing procedures and billing practices.

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The startup, which claimed to test users' stool samples using cutting edge medical technology, had raised more than $104 million in private venture capital from top firms like 8VC and Andreessen Horowitz. Before filing Chapter 11 on Wednesday, the buzzy startup was worth more than $600 million, according to Pitchbook data.

Read More: Raising a series A round used to be a victory lap for startups. Thanks to Softbank, it's become one of the most competitive rounds with the highest stakes.

But as flame outs go, uBiome is hardly the exception to Silicon Valley's rule. In fact, the company was only the fourth largest to go under so far in 2019. The top 11 now-defunct startups raked in more than $889 million in private venture capital during their lifetimes, and range from consumer robotics makers and blockchain startups all the way to comic book inspired monthly subscription boxes.

Although concentrated in California's Silicon Valley, startups around the country were not spared from the financial Grim Reaper. Two Maryland-based startups bit the dust, as did others in Virginia and Boston, Massachusetts.

Here are the 11 most valuable startups that have gone under so far in 2019, according to Pitchbook data.