Meet the Sacklers, one of the richest families in America, who built their $14 billion fortune off of controversial prescription drug OxyContin

The Sackler family is one of the richest families in the US. In 2016, Forbes estimated their net worth at a "conservative" $14 billion, beating out famously wealthy families such as the Mellons and the Rockefellers. They own Purdue Pharma, a pharmaceutical company based in Connecticut.

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The vast majority of the Sackler fortune comes from a well-known prescription painkiller that Purdue Pharma launched in 1996: OxyContin. By 2001, sales of the drug made up approximately 80% of Purdue Pharma's revenue.

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OxyContin is seen as partly to blame for the opioid crisis sweeping the US. More than 130 people in the US die each day after overdosing on opioids, including prescription pain relievers, heroin, and synthetic opioids such as fentanyl.

Purdue Pharma, which generates $3 billion in annual sales, has spent hundreds of millions of dollars settling various lawsuits over misleading drug regulators, doctors, and patients about the risks of addiction when taking OxyContin. The Sackler family still completely owns the company, and the multibillion-dollar fortune is shared among around 20 family members.

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"The Sacklers have hidden their connection to their product," Keith Humphreys, a psychiatry professor at Stanford University who has written extensively about the opioid crisis, told Esquire. "They don’t call it 'Sackler Pharma.' They don’t call their pills 'Sackler pills.' And when they're questioned, they say, 'Well, it's a privately held firm, we're a family, we like to keep our privacy, you understand.'" But the family is well-known for their philanthropic endeavors, with their names visibly emblazoned on hospital wings and museum galleries.

The pharmaceutical empire began when brothers Mortimer and Raymond Sackler took over a small pharmaceutical company in New York City's Greenwich Village called Purdue Frederick as co-chairmen. It later became Purdue Pharma.

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The oldest Sackler brother, Arthur, worked in pharmaceutical marketing and became one of the world’s leading collectors of Asian art. He died in 1987 at age 73, before OxyContin was invented. His descendants split off from the rest of the family years ago and are "mere multimillionaires," according to Esquire.

His four children, Elizabeth Sackler, Carol Master, Arthur Felix Sackler, and Denise Marica, have said they have not made any money from OxyContin. Elizabeth, a board member of the Brooklyn Museum, where she endowed the Elizabeth A. Sackler Center for Feminist Art, has called the OxyContin-based wealth of her family members "morally abhorrent."

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The middle son and one of Purdue Pharma's chief executives, Mortimer Sackler, who died in 2010 at age 93, left behind his third wife, Theresa Sackler, who is heavily involved in philanthropic work. Of Mortimer's seven children, three are board members of Purdue Pharma.

One of those board members is his son, also named Mortimer. The other two are daughters Kathe Sackler, who is also the founder and president of the Acorn Foundation for the Arts & Sciences, and Ilene Sackler Lefcourt, director of the Sackler Lefcourt Center for Child Development.

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Mortimer Sr.'s other four children are apparently not involved in the company. Marissa Sackler, who considers herself a "social entrepreneur," is the founder of Beespace, a non-profit that supports organizations such as the Malala Fund.

Purdue Pharma's other former chief executive, Raymond Sackler, died in 2017 at age 97. He had two children: Jonathan and Richard. Both are board members at Purdue Pharma. Richard's son and Raymond's grandson, David, is also a board member.

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Raymond's granddaughter, Madeleine Sackler, is an award-winning filmmaker. In response to criticism related to her family background, she said she had "never worked at the company or had any influence in it."

The Sacklers' philanthropic endeavors have involved an assortment of well-known global institutions, many related to art. The Sacklers reportedly donated $3.5 million to the Metropolitan Museum of Art in New York City in 1974 to create the Sackler Wing, where the Egyptian "Temple of Dendur" sits.

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There's a Sackler Gallery at the Smithsonian Institution in Washington, DC.

In London, there's the Serpentine Sackler Gallery.

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There is a Sackler Center at the Guggenheim in New York City ...

... as well as a Sackler Educational Lab at the American Museum of Natural History. The list goes on.

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There's even a type of rose named after a Sackler. Some have suggested the Sacklers should instead put their money toward helping those affected by opioid addiction, The New Yorker's Patrick Radden Keefe reported.