2 of the world's biggest drugmakers just teamed up on a coronavirus vaccine, and they're aiming to launch it next year

2 of the world's biggest drugmakers just teamed up on a coronavirus vaccine, and they're aiming to launch it next year
FILE PHOTO: A health worker fills a syringe with Ebola vaccine before injecting it to a patient, in Goma, Democratic Republic of Congo, August 5, 2019. REUTERS/Baz Ratner



A health worker fills a syringe with Ebola vaccine before injecting it to a patient, in Goma.

  • Two of the world's largest pharmaceutical companies are teaming up in the hunt for a coronavirus vaccine.
  • The European drugmakers Sanofi and GlaxoSmithKline will work together on a vaccine, aiming to start human testing later this year.
  • If trials are successful, the companies estimate the vaccine could be available in the second half of 2021.
  • Visit Business Insider's homepage for more stories.

Two of the world's largest drugmakers are now working together to develop a coronavirus vaccine.

Sanofi and GlaxoSmithKline announced the collaboration Tuesday morning. They aim to start testing a potential vaccine in humans later this year to be ready for use in the second half of 2021. Financial terms of the deal weren't disclosed.

The two European pharmas each bring decades of experience in vaccine development. Their combined market value exceeds $200 billion and they employ roughly 200,000 workers.


"As the world's leading vaccine manufacturer, our number one focus is to help to develop a vaccine," GlaxoSmithKline CEO Emma Walmsley said on a Tuesday call with reporters. "This is, of course, core to the exit plan that the world needs."

Sanofi will use an antigen targeting the coronavirus' signature spike protein, and GSK will provide an adjuvant, which can reduce the amount of vaccine needed per dose. The US Biomedical Advanced Research and Development Authority (BARDA) has partially funded Sanofi's vaccine research.

BARDA Director Rick Bright said in a statement this collaboration "holds the potential to lower the vaccine dose to provide vaccine to a greater number of people to end this pandemic, and help the world become better prepared or even prevent future coronavirus outbreaks."

Read more: There are more than 40 potential coronavirus vaccines in the works. Here are the top efforts to watch, including the 8 vaccines set to be tested in people this year.

There are now 70 vaccine research efforts underway, according to the World Health Organization. Even in tapping the resources of the two drugmaking giants, the world will likely need multiple vaccines to meet the unprecedented global demand for a coronavirus vaccine, GSK executives said.


"Both companies bring significant manufacturing capacity," Walmsley said. "While we have a lot of work to do, given that this is in an early stage of development, we believe that if we're successful, we'll be able to make hundreds of millions of doses annually by the end of next year."

Sanofi and GSK stated they "are committed to making any vaccine that is developed through the collaboration affordable to the public." They said they plan to "offer fair access for people in all countries." Walmsley added this will likely include donations to some of the poorest countries.

A sharpening distinction between new- and old-school vaccine approaches

The deal also shows the contrast in approaches between some pharma giants using well-known vaccine technologies versus smaller biotechnology firms that are now applying unproven, novel approaches against the coronavirus.

These biotechs have sped past Big Pharma into clinical testing. Moderna and Inovio Pharmaceuticals have both already started dosing healthy volunteers with their experimental vaccines, which leverage new genetic technologies.

Read more: A top Wall Street analyst says there's a less than 20% chance of having a widely available coronavirus vaccine by next year. He told us why he's 'deeply skeptical' of Anthony Fauci's 18-month timeline.


Moderna is testing a messenger RNA (mRNA) vaccine that instructs human cells to produce virus-fighting proteins called antibodies. Inovio developed a DNA vaccine which delivers optimized DNA into cells to spur an immune response.

Both approaches are based on decades of research but have yet to lead to any vaccines approved by the US Food and Drug Administration. Both platforms have the advantage of using only genetic code, instead of requiring samples of the live virus. That helps speed up much of the early-stage development work.

Sanofi and GSK are using a well-established platform of a protein-based vaccine plus an adjuvant. While it will take longer to begin human testing, the companies argue they can quickly progress given the familiarity of this technology.

Sanofi is also working with a tiny Massachusetts biotech called Translate Bio to advance an mRNA coronavirus vaccine. GSK is supplying its adjuvant technology to other vaccine programs from the University of Queensland, the Chinese biotech Clover Biopharmaceuticals, and Xiamen Innovax Biotech.

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The big pharmas overshadow smaller biotechs in terms of resources, both in capital on-hand and existing infrastructure. Manufacturing a vaccine in quantities large enough to meet worldwide demand is expected to present a challenge for companies of every size.

GSK and Sanofi did not provide an estimate of their combined production capacity in Tuesday's release. Sanofi has previously stated it can make hundreds of millions of doses per year of a coronavirus vaccine with its existing production plants.

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