She called the pandemic a natural disaster and said we "can use science to try and cope" with it.
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Dr. Anthony Fauci and Dr. Rochelle Walensky have both been blamed for a lot since the pandemic began.
Fauci, who directs the US infectious-disease response at the National Institutes of Health, heads up the massive federal agency that helps develop vaccines and treatments.
Fauci has spoken openly about the hate mail, suspicious powders, and threatening calls he and his family have received during the pandemic. He said the divisiveness and raw hatred he saw today was far worse than any of the protests or deaths threats he received during the HIV crisis in the late 1980s and early '90s.
"I have threats upon my life, harassment of my family and my children with obscene phone calls, because people are lying about me," he said earlier this month during a US Senate hearing.
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Speaking with Insider on her first anniversary at the helm of the CDC, Walensky said Fauci's experience "resonates with me."
Walensky said there was a simple, psychological reason some people were so eager to point a finger and threaten her and Fauci.
Fauci and Walensky are the 'easy targets' for people who want 'somebody to blame,' the CDC head says
"If you equate this pandemic to a natural disaster, which is what I think it is, we have many different ways that we can use science to try and cope and to improve outcomes, improve life, life expectancy, survival from this natural disaster," Walensky said.
She acknowledged that the agency had room for improvement in its COVID-19 response, in terms of clear and honest communication to the public and in speeding up the science that undergirds recommendations and shifts in guidance.
"We even have to act in times where we have imperfect information because the situation is imperfect," she said.
"I want to read and hear the criticism," she added, "but I also want to make sure that it's balanced by all these incredible people who have been here to support me."
Read our full interview with CDC Director Rochelle Walensky here.
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