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In the interview, Wayne was asked whether he regretted saying that there's "no such thing as racism" in September. The rapper denied regretting his comments, and then the interviewer, Lindsey Davis, probed Wayne about the Black Lives Matter movement.
"What is it? What - what do you mean?" Wayne asked Davis, apparently unaware of the cultural movement that many high-profile musicians have openly supported over the past few years, in response to the numerous police killings of unarmed black men and women.
After Davis clarified, Wayne responded, "That just sounds weird. I don't even know why you put a name on it. It's not a name. It's not 'whatever, whatever.' It's somebody got shot by a policeman for a f----d-up reason."
The 34-year-old rapper then seemed to elaborate on what he sees as the absence of racism in his personal life.
"I am a young, black, rich motherf-----," Wayne said. "If that don't let you know that America understand black motherf-----s matter these days, I don't know what it is. Don't come at me with that dumb sh-t, ma'am. My life matter, especially to my b--ches.
"I don't feel connected to a damn thing that ain't got nothin' to do with me," he added. "If you do, you crazy as s--t."
Wayne then abruptly ended the interview by removing his microphone and telling the "Nightline" production crew, "I ain't no f----n' politician."
Watch the interview below: