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Jerry Seinfeld suffered several setbacks before his big break.
But as some of the world's most successful people prove, failure is often par for course.
Grit, perseverance, resilience - whatever you call it, many influential people show that the key to success is the ability to embrace failure and adapt to change change with confidence.
For a little inspiration, we've put together a list of indisputable successes, from movie stars to scientists, who had to rebound from massive failure before they found fame and fortune.
Scroll on to see the underdogs who went on to change the world.
Rachel Sugar contributed to an earlier version of this article.