The Gillian Flynn novel follows Nick Dunne (Ben Affleck) who is accused of murdering his wife Amy (Rosamund Pike) after she goes missing on the couple's five-year wedding anniversary.
As the case continues, Dunne becomes dubbed "the most hated man in America" by media.
The thriller is the latest from director David Fincher who brought mindbenders "Se7en" and "Fight Club" to screen. Neil Patrick Harris and Tyler Perry also star.
"Gone Girl" is in theaters October 3.