The Chicago high school was hit with tragedy two years ago when 15-year-old Hadiya Pendleton was shot and killed in a neighborhood park. The class mourned her absence, and an empty chair draped in her favorite color, purple, was left open for her.
The deceased teenager had performed at Obama's inauguration festivities.
The First Lady challenged the graduating seniors to rise above the hardship they have faced at a young age, and to bring positivity and success to themselves, their communities and the world.
And in a surprise twist, she brought a video of the cast members of the ABC show "Scandal" congratulating the class on their accomplishments.
The video was a hat tip to the King College seniors, who secured Michelle Obama as their graduation speaker after they won a student video contest that parodied "Scandal" and promoted student applications for college financial aid.
Watch the video below to see the entireity of the First Lady's graduation speech: