Ministry spokesman Lu Kang on Monday responded angrily to Pompeo's remarks, saying he was spreading lies about China.
Speaking during a four-nation tour of Latin America last week, Pompeo said Chinese financial intervention in
Lu, during a regular press briefing, said the US secretary of state had "wantonly slandered" China's relations with Latin America.
"For some time, some US politicians have been carrying the same version, the same script of slandering China all over the world, and fanning the flames and sowing discord everywhere," Lu said.
"The words and deeds are despicable. But lies are lies, even if you say it a thousand times, they are still lies. Mr Pompeo, you can stop," the spokesman said.
Amid the ongoing political crisis in Venezuela, Washington has pressed President Nicolas Maduro to step down and urged other countries to join a coalition in support of opposition leader Juan Guaido. But China, the top creditor of the country with the world's biggest oil reserves, has backed Maduro.
Lu said the US regarded Latin America as its own backyard, and had pressured, threatened and even toppled other countries' political regimes in the region.
"The Latin American countries have good judgment about who is their true friend and who is false, and who is breaking rules and making trouble," Lu said.
Lu is not the only Chinese official to have gone on the offensive over Pompeo's comments. On Sunday, China's ambassador to Chile, Xu Bu, said in an op-ed piece in Chilean newspaper El Mercurio that the US secretary of state was "totally wrong".
"Pompeo's body has entered the 21st century but his mind remains in the 20th century, full of thoughts about hegemony and the cold war," Xu wrote.
While Chinese diplomats are not shy about expressing their indignation when China is criticised, they usually follow diplomatic protocol in their counter-attacks.
Shi Yinhong, director of
"Probably the Chinese side has also given up hope on him [curbing his criticism of China] too," Shi said. "But we don't know if next time Beijing will change its tune [and soften its response]."
In February, when asked about Pompeo warning Eastern European countries of the security risks associated with cooperating with China, foreign ministry spokeswoman
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