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<ul><li>The government on Wednesday said more than 30 vaccine candidates for <keyword id="1754604" type="PERSON" weightage="20" keywordseo="coronavirus">coronavirus</keyword> have been supported, and three of them are in advance stages of trials now. </li><li>While four are in advanced pre-clinical development stage.</li></ul> The government on Wednesday said more than 30 vaccine candidates for coronavirus have been supported, and three of them are in advance stages of trials now, while four are in advanced pre-clinical development stage. Union Minister of State for Home Nityanand Rai also told the Rajya Sabha that 13 clinical trials of repurposed drugs have been undertaken to build a portfolio of therapeutic options for <keyword id="8763838" type="UNKNOWN" weightage="20" keywordseo="covid-19">COVID-19</keyword> patients. READ ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/science/health/news/covid-19-vaccine-updates-from-around-the-world/slidelist/78139366.cms">COVID-19 vaccine updates from around the world — these nine candidates are at phase III trial stage</a> "More than 30 vaccine candidates have been supported which are in different stages of development, 3 candidates are in advanced stage of Phase I, II, III trials and more than 4 are in advanced pre-clinical development stage," he said. Rai said a national expert group on vaccine administration for COVID-19 was constituted on August 7, under the NITI Aayog. SEE ALSO: <a href="https://www.businessinsider.in/science/health/news/we-wont-have-enough-covid-19-vaccine-for-everybody-until-2024-warns-worlds-largest-vaccine-producer/articleshow/78111779.cms">We won't have enough COVID-19 vaccine for everybody until 2024, warns world's largest vaccine producer</a> <a href="https://www.businessinsider.in/business/startups/news/amid-india-china-standoff-tencent-is-back-with-an-investment-in-flipkart/articleshow/78140794.cms">Amid India-China standoff, Tencent is back with an investment in Flipkart</a>

Three COVID-19 vaccine are under advance trials, 4 in advanced pre-clinical stage, says government

<keyword id="6354785" type="LOCATION" weightage="20" keywordseo="france">France</keyword> has registered a new record for the highest number of single-day Covid-19 cases, with a total of 52,010 people testing positive for the virus in a span of 24 hours, health authorities said. Sunday's figure came after Saturday's record 45,422 cases, Xinhua news agency quoted the Public Health Agency as saying. Since the beginning of the pandemic, France has registered a total of 1,138,507 coronavirus. On October 23, it became the second European country to register more than one million confirmed cases after Spain. Also on Sunday, the country reported 116 new fatalities, taking the death toll to 34,761, official data revealed. In addition, 17 per cent of those tested for the virus now have positive results in France, after reaching 16 per cent on Saturday against 15.1 per cent the day before, in comparison to just 4.5 per cent in early September. The ongoing second wave of the pandemic has forced the French government to impose tougher restrictive measures including curfews in a majority of regions across the country. More than two-thirds of the French population, or around 46 million people, have been requested to stay home between 9 p.m. and 6 a.m. for six weeks. On October 24, the National Assembly adopted at the first reading the extension of the state of health emergency until February 16, 2021. The bill authorizes the executive to introduce restrictions to face a "period which will be long and difficult", warned Health Minister Olivier Veran. The toll will "grow heavier in the coming days and weeks, whatever we do" due to the dynamics of the epidemic, he added. SEE ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/stock-market/news/ril-future-retail-stocks-under-pressure-after-singapore-arbitration-court-rules-in-favour-of-amazon/articleshow/78865963.cms">RIL, Future Retail stocks under pressure after Singapore arbitration court rules in favour of Amazon</a>

France reports new record high single-day Covid-19 cases

In a major global study, researchers have revealed that long-term exposure to air pollution may be linked to 15 per cent of Covid-19 deaths worldwide. According to the study, published in the journal Cardiovascular Research, in Europe the proportion was about 19 per cent, in North America it was 17 per cent, and in East Asia about 27 per cent. "Since the numbers of deaths from Covid-19 are increasing all the time, it's not possible to give exact or final numbers of Covid-19 deaths per country that can be attributed to air pollution," said study author Jos Lelieveld from Max Planck Institute in Germany. "However, as an example, in the UK there have been over 44,000 <keyword id="1754604" type="PERSON" weightage="20" keywordseo="coronavirus">coronavirus</keyword> deaths and we estimate that the fraction attributable to air pollution is 14 per cent, meaning that more than 6,100 deaths could be attributed to air pollution," Lelieveld added. The researchers used epidemiological data from the previous US and Chinese studies of air pollution and Covid-19 and the SARS outbreak in 2003, supported by additional data from Italy. They combined this with satellite data showing global exposure to polluting fine particles known as 'particulate matter' that is less than or equal to 2.5 microns in diameter (known as PM2.5) to create a model to calculate the fraction of coronavirus deaths that could be attributable to long-term exposure to PM2.5. The results are based on epidemiological data collected up the third week in June 2020 and the researchers said that a comprehensive evaluation will need to follow after the pandemic has subsided. Estimates for individual countries show, for example, that air pollution contributed to 29 per cent of coronavirus deaths in the Czech Republic, 27 per cent in China, 26 per cent in Germany, 22 per cent in Switzerland, 21 per cent in Belgium, 19 per cent in The Netherlands, 15 per cent in Italy and 14 per cent in the UK. Referring to previous work that suggests that the fine particulates in air pollution may prolong the atmospheric lifetime of infectious viruses and help them to infect more people. Lelieveld said: "It's likely that particulate matter plays a role in 'super-spreading events' by favouring transmission." According to the researchers, the particulate matter seems to increase the activity of a receptor on cell surfaces, called ACE-2, that is known to be involved in the way Covid-19 infects cells. "So, we have a 'double hit': air pollution damages the lungs and increases the activity of ACE-2, which in turn leads to enhanced uptake of the virus by the lungs and probably by the blood vessels and the heart," the authors wrote. SEE ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/science/space/news/china-launches-three-new-spy-satellites-amid-border-dispute-with-india-and-tensions-in-the-south-china-sea/articleshow/78886330.cms">China launches three new spy satellites amid border dispute with India and tensions in the South China Sea</a> <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/stock-market/news/indian-equity-markets-trade-higher-led-by-banking-consumer-good-stocks/articleshow/78886121.cms">Indian equity markets trade higher led by banking, consumer good stocks</a>

Air pollution ups COVID-19 deaths by 15% worldwide, claims study

<ul><li> In a fight against the <keyword id="8763838" type="UNKNOWN" weightage="20" keywordseo="covid-19">Covid-19</keyword> pandemic, new research adds to the growing body of evidence that vitamin D deficiency may raise the risk of getting novel <keyword id="1754604" type="PERSON" weightage="20" keywordseo="coronavirus">coronavirus</keyword>. </li><li>Vitamin D is a hormone, produced in the skin during exposure to sunlight, and helps regulate the amount of calcium and phosphate in the body, which are needed to keep bones, teeth and muscles healthy.</li></ul> In a fight against the Covid-19 pandemic, new research adds to the growing body of evidence that vitamin D deficiency may raise the risk of getting novel coronavirus. Vitamin D is a hormone, produced in the skin during exposure to sunlight, and helps regulate the amount of calcium and phosphate in the body, which are needed to keep bones, teeth and muscles healthy. In a retrospective study of patients tested for Covid-19, published in the journal JAMA Network Open, the researchers found an association between vitamin D deficiency and the likelihood of becoming infected with the coronavirus. "Vitamin D is important to the function of the immune system and vitamin D supplements have previously been shown to lower the risk of viral respiratory tract infections," said study lead author David Meltzer from the University of Chicago (UChicago) in the US. "Our statistical analysis suggests this may be true for the Covid-19 infection," Meltzer added. For the study, the research team looked at 489 UChicago Medicine patients whose vitamin D level was measured within a year before being tested for Covid-19. The findings showed that patients who had vitamin D deficiency, that was not treated, were almost twice as likely to test positive for the Covid-19 coronavirus compared to patients who had sufficient levels of the vitamin. "Half of Americans are deficient in Vitamin D, with much higher rates seen in African Americans, Hispanics and individuals living in areas like Chicago where it is difficult to get enough sun exposure in winter," the researchers wrote. "Understanding whether treating Vitamin D deficiency changes Covid-19 risk could be of great importance locally, nationally and globally," Meltzer said. Vitamin D is inexpensive, generally very safe to take, and can be widely scaled. The research team emphasized the importance of experimental studies to determine whether vitamin D supplementation can reduce the risk, and potential severity, of Covid-19. They also highlight the need for studies of what strategies for vitamin D supplementation may be most appropriate in specific populations. They have initiated several clinical trials at UChicago Medicine and with partners locally. Earlier, another study published in the journal FEBS, found that low levels of Vitamin D in the blood are associated with an increased risk of Covid-19 infection. SEE ALSO: <a href="https://www.businessinsider.in/business/news/pubg-ban-india-makes-chinese-company-tencent-loses-34-billion-in-2-days/articleshow/77924912.cms">Tencent loses nearly $34 billion since the PUBG ban in India — its second-largest valuation dip this year</a>

Vitamin D deficiency may raise risk of getting Covid-19

New Delhi, Mar 1 () After posting their worst week since the 2008 financial crisis, Indian equity benchmarks will take further cues from global markets in the coming sessions as investors assess the impact of the coronavirus outbreak, analysts said. The BSE Sensex logged its second-biggest one-day fall in history on Friday, mirroring a carnage in world equities amid fears that the virus epidemic may turn out to be a bigger threat to the global economy than initially anticipated. More than 85,000 people have been infected in over 50 countries and over 2,900 have died. According to Vinod Nair, Head of Research at Geojit Financial Services, the risk to markets will increase if the infection lasts longer and continues to spread at a fast pace. "The numbers, regarding the spread of the disease, and how far it can be contained, will drive the markets next week. Measures by governments to boost respective economies will also be watched out for, post the Chinese government's support to bolster the economy," he said. Stocks are also expected to react to the GDP growth numbers released after market hours on Friday. India's gross domestic product (GDP) growth slipped to a nearly 7-year low of 4.7 per cent in October-December 2019, weighed by a contraction in manufacturing sector output. "Markets may have fallen on the coronavirus scare, but it may be worthwhile to ponder on the direct relationship between GDP growth and earnings growth to understand whether the markets have run ahead of the earnings trajectory, at least for some time now," said Joseph Thomas, Head of Research - Emkay Wealth Management. In the forthcoming week, investors will also track SBI Cards IPO and RITES OFS by the government, said Jimeet Modi, Founder and CEO, SAMCO Securities &amp; StockNote. "However, no matter the outcome, markets would broadly be driven by the virus and global sentiment," he added. Fundamentally, Indian bourses have been trading at higher valuations and hence a correction was needed to align the markets as per the mean reversion theory, he pointed out. "Hence, this week's fall is a valuation play with coronavirus as the scapegoat. The frothy valuations needed the markets to correct," he said. The BSE Sensex crashed 1,448.37 points, or 3.64 per cent, to close at 38,297.29 on Friday. During the week, the Sensex plunged 2,872.83 points or 6.97 per cent, and the NSE Nifty tumbled 879.10 or 7.27 per cent. ANS ABM

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Three COVID-19 vaccine are under advance trials, 4 in advanced pre-clinical stage, says government

PTI

France reports new record high single-day Covid-19 cases

IANS

Air pollution ups COVID-19 deaths by 15% worldwide, claims study

IANS

Vitamin D deficiency may raise risk of getting Covid-19

IANS

Coronavirus updates to dictate market trend next week: Analysts

PTI

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