Covid-19 infections may predispose individuals to developing irreversible neurological conditions, finds a study. The study by <keyword id="3610521" type="General" weightage="50" keywordseo="houston-methodist" source="Orion">Houston Methodist</keyword> researchers showed that <keyword id="8764262" type="General" weightage="100" keywordseo="covid" source="Orion">Covid</keyword> infection may increase the likelihood of strokes and may increase the chance of developing persistent brain lesions that can lead to brain bleeding. Covid-19 is known to invade and infect the brain, among other major organs. Several brain imaging studies on Covid victims and survivors have confirmed the formation of microbleed lesions in deeper brain regions related to our cognitive and memory functions. In the review study, published in the journal Ageing Research Reviews, researchers have critically evaluated the possible chronic neuropathological outcomes in ageing and comorbid populations if timely therapeutic intervention is not implemented. Microbleeds are emerging neuropathological signatures frequently identified in people suffering from chronic stress, depressive disorders, diabetes and age-associated comorbidities. Based on their earlier findings, the investigators discuss how Covid-induced micro-haemorrhagic lesions may exacerbate DNA damage in affected brain cells, resulting in neuronal senescence and activation of cell death mechanisms, which ultimately impact brain microstructure-vasculature. These pathological phenomena resemble hallmarks of neurodegenerative conditions like Alzheimer's and Parkinson's diseases and are likely to aggravate advanced-stage dementia, as well as cognitive and motor deficits. Further, the review includes Covida�s predispositions for Alzheimer's, Parkinson's and related neurodegenerative diseases, as well as cardiovascular disorders due to internal bleeding and blood clotting-induced lesions in the part of the brain that regulates our respiratory system, following the Covid symptoms. In addition, cellular ageing is thought to be accelerated in Covid patients. A plethora of cellular stresses inhibit the virus-infected cells from undergoing their normal biological functions and let them enter into "hibernation mode" or even die completely. The study also suggests various strategies to improve some of these long-term neuropsychiatric and neurodegenerative outcomes, as well as outlines the importance of the therapeutic regimen of the "nanozyme" in combination with various FDA-approved drugs that may prove successful to fight against this catastrophic disease. However, given the ever-evolving nature of this field, associations like the ones described in this review show the fight against Covid is far from over, said the researchers, and reinforce the message that getting vaccinated and maintaining proper hygiene are key in trying to prevent such long-term and detrimental consequences. SEE ALSO : <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/personal-finance/news/missed-filing-your-tax-returns-heres-what-you-pay-in-late-fee-penalties/articleshow/93275795.cms">Missed filing your tax returns? Here’s what you pay in late fee &amp; penalties</a> <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/india/news/casino-organizers-in-hyderabad-grilled-by-ed-over-fema-violations/articleshow/93275739.cms">Casino organizers in Hyderabad grilled by ED over FEMA violations</a>

Covid infection may accelerate brain ageing says new study

Scientists have developed a new laser-based breathalyser test powered by artificial intelligence (AI) that they say can detect COVID-19 in real-time with excellent accuracy. The team from the University of Colorado (CU) <keyword id="107195" type="General" weightage="50" keywordseo="boulder" source="Orion">Boulder</keyword> in the US hopes that the frequency comb breathalyser-essentially using laser light to distinguish one molecule from another-could revolutionise medical diagnostics. "Our results demonstrate the promise of breath analysis as an alternative, rapid, non-invasive test for COVID-19 and highlight its remarkable potential for diagnosing diverse conditions and disease states," said study first author <keyword id="17375478" type="General" weightage="80" keywordseo="qizhong-liang" source="Orion">Qizhong Liang</keyword>, a <keyword id="6435115" type="General" weightage="20" keywordseo="phd" source="Orion">PhD</keyword> candidate at CU Boulder. "There is a real, foreseeable future in which you could go to the doctor and have your breath measured along with your height and weight...Or you could blow into a mouthpiece integrated into your phone and get information about your health in real-time," said <keyword id="2818533" type="General" weightage="80" keywordseo="jun-ye" source="Orion">Jun Ye</keyword>, adjoint professor at CU Boulder and senior author of the study published in the Journal of Breath Research. Between May 2021 and January 2022, the research team collected breath samples from 170 CU Boulder students who had, in the previous 48 hours, taken a polymerase chain reaction (PCR) test, either by submitting a saliva or a nasal sample. Half had tested positive, half negative. Overall, the process took less than one hour from collection to result. When compared to PCR, the gold standard COVID test, breathalyser results matched 85 per cent of the time. For medical diagnostics, accuracy of 80 per cent or greater is considered "excellent". The researchers noted that the accuracy would likely have been higher if the breath and saliva/nasal swab samples were collected at the same time. Unlike a nasal swab, the breathalyser is non-invasive. And unlike a saliva sample, users are not asked to refrain from eating, drinking or smoking before using it, the researchers said. The test doesn't require costly chemicals to break down the sample. And the test could, conceivably, be used on individuals who are not conscious, they said. The breathalyser test consists of a complex array of lasers and mirrors about the size of a banquet table. A breath sample is piped in through a tube as lasers fire invisible mid-infrared light at it at thousands of different frequencies. Dozens of tiny mirrors bounce the light back and forth through the molecules so many times that the light travels about 1.5 miles. Because each kind of molecule absorbs light differently, breath samples with a different molecular make-up cast distinct shadows. The machine can distinguish between those different shadows or absorption patterns, boiling millions of data points down to-in the case of COVID-a simple positive or negative, in a matter of seconds. The researchers are working to miniaturise such systems to a chip scale, allowing for what <keyword id="344472" type="General" weightage="80" keywordseo="liang" source="Orion">Liang</keyword> imagines as "real-time, self-health monitoring on the go". SEE ALSO: <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/business/auto/news/mg-motor-india-plans-to-dilute-majority-stakes-to-local-partners/articleshow/100127874.cms">MG Motor India plans to dilute majority stakes to local partners</a> <a target="_blank" class="c-link c-message_attachment__title_link" href="https://www.businessinsider.in/investment/news/investment-supertrends-2023-ai-to-digitalisation-and-green-energy/articleshow/100126382.cms">AI to digitalisation and green energy: Supertrends defining investment for today and the future</a>

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Covid infection may accelerate brain ageing says new study

IANS

New AI-powered breathalyser can 'sniff out' Covid in real-time

PTI