We picked March Madness favorites, sleepers, and Cinderellas for every region in the bracket

AP Photo/Steve Helber

Which teams will make the Final Four? There's no way of knowing, but we can give our best guess.

• March Madness is back!
• For those filling out brackets, you have until noon on Thursday to finalize your picks.
• Below we break down the bracket region-by-region, covering the favorites, contenders, and sleepers to represent the Final Four.
• Check out the rest of our March Madness coverage here.

March Madness has once again taken over the sports world, with 68 teams contending for the NCAA national championship.

Filling out a bracket can be a daunting task, and while it's fun to fuss over a first-round upset, the picks that will make or break your bracket is your Final Four - nail three of the last four teams remaining in the tournament, and you have a great shot at cashing in your office pool.

Over the past 25 years, the average sum of the Final Four seeds has hovered around 11. That can translate to two top seeds, a No. 3 and a No. 6, or any other number of combinations. Still, every few years or so, an especially impressive team makes a run late in the tournament, as Loyola-Chicago did in 2018.

To account for every possibility, and give you the best chance and filling out a perfect Final Four, below we've broken the bracket down region-by-region, going through the top team, a contender, and a sleeper in every quadrant of the bracket.