At the outbreak of World War II on Sep. 3, 1939, Churchill was appointed to the British Admiralty, thus ending his "exile." The next year, he was elected prime minister at the age of 62.
Edison went on to hold more than 1,000 patents and invented some world-changing devices, like the phonograph, practical electrical lamp, and a movie camera.
But Winfrey rebounded and became the undisputed queen of television talk shows before amassing a media empire. Today she is worth an estimated $2.9 billion, according to Forbes.
Several more of his businesses failed before the premiere of his movie "Snow White." Today, most childhoods wouldn't be the same without his ideas.
He went on to create the first summer blockbuster with "Jaws" in 1975, and has won three Academy Awards.
But at the age of 36, Macy launched R.H. Macy & Co., which grew to become Macy's, one of the largest department store chains in the world.
Honda was a mechanical genius who idolized Edison and rebelled against the norm. His passion for aggressive individualism was more fit for the United States, and thus alienated him from Japanese businessmen, who valued teamwork above all else. Honda then boldly challenged the American automotive industry in the 1970s and led a Japanese automotive revolution.
He traveled across the U.S. looking for someone to sell his fried chicken, and after finally getting a business deal in Utah, Kentucky Fried Chicken was born. KFC is now one of the most recognizable franchises in the world, with over 18,000 locations.
George W. Bush once joked: "So now we know if you graduate from Yale, you become president. If you drop out, you get to be vice president."
Realizing her son was not meant to till the land, she let Newton finish his basic education and was eventually persuaded to allow him to enroll in Cambridge University. Newton went on to become one of the greatest scientists of all time, revolutionizing physics and mathematics.
She began designing wedding gowns at age 40 and today is one of the premier designers in the fashion industry, with a business worth over $1 billion.
Poitier worked on his craft and eventually became a hugely successful Hollywood star. He won an Academy Award for Best Actor and helped break down the color barrier in the American film industry.
Of course, Einstein's communication and behavioral problems were not indicative of a lack of intelligence. He won the Nobel prize in physics for correcting the deficiencies of Newtonian physics with his theory of relativity.
Astaire went on to become a Hollywood and Broadway legend.
Rowling is now internationally renowned for her seven-book Harry Potter series and, in U.S. currency, became the first billionaire author in 2004.
But as Darwin studied nature, he found his true calling and traveled the world to uncover nature's mysteries. His writings, especially "On the Origin of the Species," fundamentally changed the world of science by spreading the discovery of evolution.
If he had given up his artistic career after it proved to strain his financial and emotional well-being, the art world would be missing hundreds of paintings from a true master.
Ford's career went on to span six decades, and has included timeless starring roles in blockbuster films like the "Star Wars" and "Indiana Jones" series.
Dr. Seuss became a legendary children's author known around the world for classics like "The Cat in the Hat" and "Green Eggs and Ham." His books have sold over 600 million copies.
Then she got her big break when CBS picked up her and her husband Desi Arnaz's vaudeville act and turned it into the highly influential sitcom "I Love Lucy."
However, after conducting a search, he was finally able to find a partner who had faith in him. Ford proved he had learned from his mistakes when Ford Motor Company forever changed the automotive industry and culture with his assembly line mode of production.
But the 5,127th prototype worked, and the Dyson brand became the best-selling bagless vacuum brand in the United States. He is now worth an estimated $4.5 billion, according to Forbes.
King's wife Tabitha found the manuscript in the trash and took it out. "Carrie" became a hit and launched his career. His novels have since sold over 350 million copies.
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