Moderna's groundbreaking coronavirus vaccine was designed in just 2 days
- The FDA granted emergency authorization to
Moderna's coronavirus vaccineon Friday.
- The vaccine was found to be 94.5% effective at protecting people against
- It took less than a year to develop and test the vaccine — years faster than previous vaccines.
- The company designed its vaccine in just two days. In the past, traditional vaccines have taken years to design.
The Food and Drug Administration granted emergency authorization to Moderna's
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That wouldn't have been possible without the technology Moderna has bet on since its founding: messenger RNA (mRNA) vaccines.Messenger RNA is genetic material that tells cells how to make proteins. So Moderna's coronavirus vaccine candidate works by injecting a small piece of mRNA from the coronavirus that codes for the virus' spike protein. This protein helps the coronavirus attach to and invade cells, and it's what antibodies target and neutralize. Moderna's mRNA vaccine spurs the body to produce the spike protein internally. That, in turn, triggers an immune response.
Pfizer's candidate also relies on mRNA.Utilizing mRNA technology meant that both Pfizer and Moderna only needed the coronavirus' genetic sequence to make a vaccine - no virus had to be cultivated in labs. That's why the companies were able to progress in record time. By contrast, the development of more traditional vaccines can take years. "What you could probably do is make this a whole new way of making drugs, vaccines, almost anything," Bob Langer, one of Moderna's founders, previously told Business Insider.
The FDA has never approved an mRNA-based vaccine or treatment before, so to many, Moderna's bet looked risky. But now that the FDA has given the green light to the shots, mRNA vaccines are poised to set a new industry standard.
How Moderna got ahead of the coronavirusOn January 6, Moderna CEO Stéphane Bancel emailed Barney Graham, a vaccine researcher at the National Institutes of Health. Bancel was troubled by the mysterious virus outbreak in Wuhan. He then talked with Graham about developing a vaccine.
Moderna had been working with the NIH on vaccines since 2017, but had not yet gotten one approved. Graham signed on to the partnership.
On January 11, researchers from China published the genetic sequence of the coronavirus. Two days later, Moderna's team and NIH scientists had finalized the targeted genetic sequence they would use in the vaccine."This is not a complicated virus," Bancel told The New York Times.
Moderna's speed has led some to worry that the company sacrificed thoroughness. But that's not the case, according to Albert Rizzo, chief medical officer for the American Lung Association."We're not skipping steps - we actually have better technology," Rizzo told Business Insider. "Why did it take two weeks to cross the Atlantic back in the 1800s? Well, we had to go on a boat. Whereas now, you can get across the ocean in several hours."
The pros and cons of mRNA vaccines
For decades, vaccines contained a dead or weakened version of the virus itself. Then early advances in genetics allowed vaccines to use proteins made by the virus instead. That method was first used in the 1980s to develop a vaccine for hepatitis B.Companies like Novavax are relying on that protein-based model to create their coronavirus vaccine candidates. But Moderna's business has revolved around mRNA since it started in 2010. RNA vaccines' big advantage is the speed of development and production. But there are drawbacks. For one, both Pfizer and Moderna's vaccines require two injections. Pfizer is delivering its two shots three weeks apart, while Moderna's are four weeks apart.
The vaccines are also difficult to deliver and store. Pfizer's vaccine needs to be shipped at -94 degrees Fahrenheit, which requires dry ice and special freezers. Moderna's requires a temperature of -4 degrees Fahrenheit.
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