Just like with the main psychoactive ingredient in traditional marijuana, THC, the psychoactive ingredients in synthetic marijuana bind to the brain's CB1 receptors. Because spice is so much stronger, however, it is much more likely to cause everything from seizures to psychosis.
For example, the first form of the psychoactive ingredient used in spice was called JWH-018, named for the initials of the scientist John W. Huffman who first invented it in 2008.
Many experts say "synthetic marijuana" is a huge misnomer for these drugs, since they produce far different effects and can be up to 100 times more potent than traditional marijuana.
So far this year, poison centers received reports of 3,548 exposures to synthetic marijuana, according to the American Association of Poison Control Centers.
next slide will load in 15 secondsSkip AdSkip AdRegardless, the drugs have continued to soar in popularity.
The back of these packages often includes the coy warning, "Not intended for human consumption."
Often, the drugs are packaged as "plant food" or "potpourri" so they can be legally sold in stores.
The stuff inside is then rolled up and smoked.
Next, they use the liquid to douse dry plant matter, and package it up in shiny metallic baggies.
next slide will load in 15 secondsSkip AdSkip AdThere, wholesale buyers purchase the drugs and turn them into liquids by dissolving them in acetone or alcohol.
Here's a small bag of the powdered drug, before it's been liquefied and added to plant material.
...and shipped to the US in huge containers labeled "fertilizer" or "industrial solvent."
Then they are packed up in large bags...
The drugs are created in powdered form in giant underground laboratories like this one. Many of the labs are in China.
next slide will load in 15 secondsSkip AdSkip AdThe drugmakers change up the specific ingredients in the drugs so fast — and produce them in such massive quantities — that drug enforcement can't keep up.
Reports suggest that since 2009, drugs like spice, or synthetic marijuana, have killed roughly 1,000 Americans — many of them young people in high school.
This is spice. It looks fairly harmless — like herbs in a shiny package — but it isn't.