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11 popular weight loss supplements and the scientific research behind them

Rebecca Strong,Samantha Cassetty   

11 popular weight loss supplements and the scientific research behind them
  • Common weight loss supplements like green tea extract and caffeine may help you lose some weight.
  • Most dietary supplements work by curbing appetite, boosting metabolism, or facilitatating fat burn.
  • But adding a supplement to your diet will not help you lose as much weight as eating healthy.

These days, you may find yourself inundated with advertisements for products that promise to $4.

These weight loss supplements often contain plant-based extracts that are purported to help control your appetite, boost your metabolism, or facilitate fat burning. And they're extremely popular.

The global market for weight loss products and services hit $4 in 2021, and it's estimated to reach $377.3 billion by 2026.

With an ever-increasing variety of weight loss supplements out there, it's next to impossible to research them all to evaluate the pros and cons and determine which — if any — might work for you.

Here's what experts and current research say about some of the most popular $4, and whether or not they're actually effective.

Do weight loss supplements work?

Before we get into the details, there are a few things you should know about dietary supplements (not to be confused with $4 proven to aid weight loss.)

While these "quick fixes" may be tempting, $4 registered dietitian Nick Sopczak says most don't lead to substantial weight loss, especially without making other lifestyle changes, like improving your diet and increasing physical activity.

A $4 of dietary supplements found that out of over 300 studies only 16 had sufficient evidence for significant weight loss. The vast majority of the studies' results were unreliable due to factors like bias and duration, the researchers reported.

The review also noted that dietary supplements are $4 as many other prescription and over-the-counter drugs, meaning those products can be marketed without the same level of quality testing to demonstrate their efficacy.

According to Sopczak, another issue is that much of the research on these supplements is funded by the weight loss industry, which means results are more likely to highlight the benefits while downplaying any negative aspects.

Many popular supplements are not only ineffective, but have harmful side effects, like $4, $4, elevated heart rate, or kidney problems, says Sopczak.

With that, here's a list of 11 common dietary supplements.

1. Caffeine

How it works: Research suggests that $4 may support weight loss by $4 and $4, says $4, MD, an endocrinologist at $4 and medical director of the $4.

What the research says: A small $4 found that overweight and obese participants who drank 200 milliliters of coffee along with breakfast consumed fewer calories at the following meal and throughout the day compared to those who drank water. This effect was even more dramatic in the group who drank coffee with a higher amount of caffeine.

Overall effectiveness: While caffeine alone won't likely make you lose weight, it may be an effective addition to your overall weight loss plan, says Sopczak.

Side effects: If you are $4 and consume too much, you may experience side effects like restlessness, insomnia, jitters, and anxiety.

2. Green coffee extract

How it works: $4 comes from coffee beans that haven't been roasted yet — and these unroasted beans contain natural antioxidants known as $4 that are believed to reduce the amount of glucose, aka sugar, you absorb after a meal. Excess glucose is what your body stores as fat, so absorbing less may help with weight loss by $4.

What the research says: A $4 of three studies found that overweight or obese adults who took a green coffee extract supplement alongside their normal diet lost about 5.4 pounds, on average, compared to those who took a placebo. More research is needed, researchers said, since studies had very small sample sizes, short durations, and a strong risk of bias.

Overall effectiveness: Larger, more well-designed studies are needed to determine whether or not green coffee extract is actually effective, says Sopczak — but the $4 it may help you lose a small amount of weight.

Side effects: While green coffee beans have less caffeine than roasted coffee beans, you may still experience $4, says Sopczak — like irritability, anxiety, jitteriness, headache, insomnia, and irregular heartbeat. To be safe, green coffee extract should be avoided by $4, who have heart disease or high blood pressure, or who are $4.

3. Green tea extract

How it works: $4 extract is high in catechins, a type of antioxidant believed to assist weight loss by $4, a hormone that helps burn fat while also $4, says Sopczak. The caffeine in green tea extract may also promote weight loss.

What the research says: Results from studies on green tea extract for weight loss are mixed. According to a $4 of 15 studies totaling 499 participants, two studies found green tea extract helped participants burn anywhere from 43.8 to 260.8 extra calories per day. However, it's worth noting these effects were most apparent when participants were also exercising.

Overall effectiveness: According to the $4 (NCCIH), it has yet to be proven that green tea extracts can produce meaningful, sustainable weight loss. Plus, it's difficult to determine whether green tea extract is $4or if the caffeine in the extract is what's driving studies' results.

Side effects: Green tea extract is generally well-tolerated, says Sopczak, but may cause $4 like anxiety, sleeping problems, or irritability in people who are caffeine sensitive or who take large doses — above $4.

4. Garcinia cambogia extract

How it works: More recent studies suggest that garcinia extract, which comes from a fruit native to Indonesia, can reduce a fat-producing enzyme called citrate lyase and increase levels of $4, thus potentially helping to $4, says Sopczak — but most of these studies have been $4.

What the research says: A $4 of 17 clinical trials totaling 873 subjects found garcinia cambogia had limited to no impact on weight loss. While a separate $4 found garcinia cambogia supplementation can lead to a small short-term weight reduction compared with a placebo, all of the studies examined had design weaknesses that likely affected the outcomes, the review's researchers reported.

Overall effectiveness: The $4 has concluded garcinia cambogia has "little to no effect" when it comes to weight loss.

Side effects: Possible $4 associated with this supplement mainly include gastrointestinal symptoms like nausea and diarrhea but in rare cases, it's been linked to liver damage.

5. Glucomannan

How it works: Glucomannan is a type of dietary fiber found in elephant yams. When it absorbs water in your gut, it $4 — and by taking up more room in your stomach, it's thought to help you feel more full so you eat fewer calories, says Sopczak.

What the research says: A $4 of 176 overweight, otherwise healthy, subjects found those who took a glucomannan supplement lost more than those who took a placebo — about 8-10 pounds over the course of five weeks. However, other studies $4 between glucomannan and weight loss.

Overall effectiveness: According to the $4, this supplement has little to no effect on weight loss.

Side effects: Glucomannan can cause $4 and $4, says Sopczak, and is $4 for people with gut or esophageal disorders.

6. Conjugated Linoleic Acid

How it works: Conjugated Linoleic Acid (CLA), a type of fat $4 products, may reduce appetite, $4, and help with fat burning, says Sopczak.

What the research says: A $4 of 18 studies found taking CLA was associated with losing 0.2 pounds per week for up to 6 months.

Overall effectiveness: According to the NIH, CLA might help you lose a "very small amount" of weight as well as body fat.

Side effects: CLA can cause some $4 like constipation and diarrhea, and if taken over the long-term, Sopczak says it may increase your $4.

7. Guar gum

How it works: Guar gum, a type of $4 extracted from guar beans, may help you feel fuller longer, thereby reducing how much you eat, says Sopczak.

What the research says: A $4 of 20 trials found taking a guar gum supplement resulted in less than 1 pound of weight loss — and that the risk of adverse events like abdominal pain, diarrhea, gas, and cramps outweighed any potential benefits.

Overall effectiveness: The $4 has concluded that taking guar gum "probably doesn't" help you lose weight. Guar gum may help to control appetite, but this $4 without unpleasant side effects simply by $4 such as oats, barley, apples, and oranges.

Side effects: Guar gum may cause gastrointestinal symptoms or $4 in some people, says Sopczak.

8. Bitter Orange

How it works: Extract from the bitter orange fruit contains synephrine, a compound with stimulant effects believed to $4 and $4.

What the research says: A $4 of 23 studies totaling about 450 participants found nine of the studies showed that synephrine may cause an increase in metabolic rate, suggesting it may be beneficial in weight management. However, researchers said well-controlled, longer-term studies involving only bitter orange extract are needed since about two-thirds of subjects also consumed caffeine, which may have impacted results.

Overall effectiveness: While bitter orange extract may slightly suppress appetite and increase how many calories you burn, the $4 says the word is still out on whether it can actually help you lose weight.

Side effects: The chemical $4, which has been $4 by the US Food & Drug Administration (FDA). Research on the potentially harmful effects of bitter orange is inconclusive — some studies found bitter orange $4, while others found it $4 (up to 100 milligrams).

9. *Ephedra

How it works: The active ingredient in ephedra, an herb that comes from an evergreen shrub, is $4 that may increase your metabolic rate, thus helping you to burn more calories and ultimately lose weight.

Important: *While you may be able to find ephedra products on the internet, the substance has been banned as a dietary supplement $4 and therefore is not a viable option.

What the research says: A $4 of nine studies totaling 534 overweight or obese participants found products containing ephedrine were associated with around 4.4 pounds of weight loss.

Overall effectiveness: Researchers have struggled to discern the effectiveness of ephedra since $4 and $4, which is known to support weight loss. Ultimately, $4 seem to far outweigh the potential benefits.

Side effects: The FDA $4 because it can $4, and in rare cases, cause $4, $4, or even $4. It's also been linked to $4 like anxiety and change in mood — especially in products that also contain caffeine, which can $4.

10. Chitosan

How it works: Chitosan is a sugar mainly derived from the outer skeletons of crustaceans. According to Sopczak, it is said to turn into a gel-like substance in the stomach which then $4, but $4.

What the research says: A $4 of 14 trials totaling 1,101 overweight or obese subjects found chitosan supplements slightly reduced body weight — by about 2.23 pounds — in overweight and obese people.

Overall effectiveness: According to the $4, chitosan does not bind to nearly enough fat to result in significant weight loss.

Side effects: Chitosan is $4, but Sopczak says possible side effects include upset stomach, nausea, bloating, and constipation.

11. Chromium

How it works: The mineral chromium is believed to $4. It also $4, which Sopczak says helps the body process carbs, fat, and protein more effectively.

What the research says: A $4 of nine trials with a total of 622 participants found overweight and obese adults who took chromium picolinate (a supplemental form of chromium) lost an average of about 2.4 pounds after 12 to 16 weeks. Researchers determined this amount of weight loss was of "debatable clinical relevance" and that more "reliable evidence" is needed to verify the efficacy of these supplements.

Overall effectiveness: The $4 says chromium may help you lose a "very small amount" of body weight and fat. $4 is absorbed in the intestines, which Sopczak says is likely too low to have a significant effect in the body.

Side effects: In supplement form, high doses of chromium can $4 and other diabetes medications.

This supplement should also be avoided by those with $4, or with $4. Kidney damage, worsened depression or anxiety, and irregular heartbeat have been reported in rare cases.

People with liver or $4, or people with anemia, should not take chromium without first talking to their doctor.

Insider's takeaway

While there's a chance some of these supplements — like green coffee extract, CLA, and chromium — may help support your weight loss efforts, Kumar says there still aren't enough randomized controlled trials to prove they result in significant, sustained weight loss on their own.

Experts agree none of these products will work miracles without $4 and exercise habits.

Because of the potential for interactions with medications and side effects, you should always talk to your health care provider before trying any of these supplements.

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