Last year, "Spy Kids" director and creator, Robert Rodriguez, said during San Diego Comic-Con panel with Collider's editor in chief Steven Weintraub that he had to fight to make the family Latin.
Rodriguez, of course, won this battle as can be seen by the Cortez family but you can see the Latin American influence on the props, set designs, and script. For example, at the beginning of the film, the medicine Juni (Daryl Sabara) uses to treat his hand warts is called "Mezqui-no." This might be a fun play on the word mezquino which in Latin America Spanish means warts.
There's also a sign that says "Peligro. Alto Voltaje" on the wall behind Juni when he sleeps at Machete's (Danny Trejo) workshop. This translates to "danger. high voltage" and the sign is set up in a way that would probably mean non-Spanish children could work it out.
Finally, at the end Fegan Floop (Alan Cumming) renames the robotic clones of Carmen and Juni as Junito and Carmenita which means little Carmen (Alexa PenaVega) and Juni, implying that the two robots are little reminders of the two children that inspired him.