Actress and women's rights activist Alyssa Milano defended Biden amid the accusations.
"I am proud to call Joe Biden a friend," Milano said in a series of tweets. "He has been a leader and a champion on fighting violence against women for many years, and I have been fortunate to accompany him to events with survivors where he has listened to their stories, empathized with them, and comforted them."
"Joe Biden's response that he never meant to make anyone uncomfortable and that he'll listen and learn from anyone who says otherwise is exactly the leadership we need to build a culture where women are heard and are equal," Milano added.
Milano, an outspoken activist and supporter of the #MeToo movement, said she respected Flores' decision to tell her story, and that her views of Biden did not diminish Flores' accusation.
"I respect Lucy Flores' decision to share her story and agree with Biden that we all must pay attention to it," Milano said on Twitter. "But, just as we must believe women that decide to come forward, we cannot assume all women's experiences are the same."
"I believe that Joe Biden's intent has never been to make anyone uncomfortable, and that his kind, empathetic leadership is what our country needs. Especially now," she added.