Clearly, Benedict Cumberbatch is reprising his role as Doctor Stephen Strange, while a slew of stars from the first movie are also returning.
Chiwetel Ejiofor will return in some capacity as Karl Mordo, an ally of Strange's in the first film who was set up as a future villain in that picture's end credits scene.
Benedict Wong will also reprise his role as fellow Master of the Mystic Arts Wong, who appeared alongside Cumberbatch's Strange in both "Avengers: Infinity War" and "Avengers: Endgame."
For a while, it didn't look like Rachel McAdams would be returning for the movie, but she was confirmed to reprise her role as Strange's ex-girlfriend and colleague, surgeon Christine Palmer.
It's unclear if any other key characters from the first movie will return, such as Michael Stuhlbarg's Nicodemus West, Benjamin Bratt's Jonathan Pangborn, Mads Mikkelsen's Kaecilius, or Tilda Swinton's The Ancient One who appeared in "Endgame."