Over the years Perlman, 74, has appeared in episodes of huge shows like "Frasier" (as Carla), "Ally McBeal," and "Law & Order: Special Victims Unit."
Perlman has also been in many short-lived television shows including "Kate Brasher," "Pearl," "Hung" and "Robot and Monster." Alongside television, she has also starred in iconic cult classic films like "Matilda" (which was directed by her husband Danny DeVito), "Class Act" and "Sunset Park."
Perlman is still acting in popular shows, and has recently appeared in series such as "The Mindy Project," "Me and My Grandma," and "The Goldbergs."
In 2022, she had a role in the coming-of-age musical film "13," which is based on the 2008 Broadway musical of the same name. Next year, she'll be in the "Barbie" film.
Outside of television and movies, she's also a children's book author. In the mid-2000s, Perlman authored the book series "Otto Undercover."
Perlman was married to her "Matilda" co-star Danny DeVito from 1982 to 2012, though they've never formally divorced. They share three children together.