Most makers of VR equipment don't recommend people with epileptic conditions or special sensitivities to rapidly changing light try the experience, but these symptoms can occur even if the user has never experienced a seizure before.
According to the instructional booklet that comes with the Oculus Rift:
Some people (about 1 in 4000) may have severe dizziness, seizures, eye or muscle twitching or blackouts triggered by light flashes or patterns, and this may occur while they are watching TV, playing video games or experiencing virtual reality, even if they have never had a seizure or blackout before or have no history of seizures or epilepsy.
The likelihood of having a VR-induced seizure is compounded by the number of hours you spend in the headset without a break, so a good rule of thumb is to treat VR like playing a sport. Every so often, take a break for water, and catch your breath.