The only club meeting the two came in the final of the 2011 FIFA Club World Cup.
The final was hosted in the NISSAN Stadium in Tennessee where Neymar's Santos, as winners of the 2011 Copa Libertadores, met Messi's Barcelona fresh from winning the 2010-11 UEFA Champions League at Wembley.
If the first meeting between the pair was tight, the second one was a blowout, with Barcelona running away 4-0 winners.
Messi scored the opening goal of the game in the 17th minute thanks to an assist from Xavi before the midfielder then scored himself in the 24th minute.
Cesc Fàbregas scored on the stroke of half time and Messi scored his second of the game to wrap up the match and secure one of soccer's most prestigious but least-sought-after trophies.