Chris Cox joined Facebook in 2005. He helped build some of the social network's most recognisable features, such as the news feed.
His departure signalled a major reshuffle at the company's highest levels following Mark Zuckerberg's announcement that he was going to make the company more privacy-focused.
In his memo announcing Cox's departure, Zuckerberg repeatedly made reference to the new emphasis on privacy.
No one will be filling Cox's shoes as chief product officer, and instead, the heads of Facebook's various apps will report directly to Zuckerberg.
Time at Facebook: 14 years