As shares of GameStop soared, the broader stock market averages sold off, with the S&P 500 and Nasdaq 100 down more than 2% on Thursday.
And while many investors are attributing the broad market decline to rising interest rates, with the 10-year US Treasury note moving above 1.5% on Thursday, Lee thinks it could actually be caused by a de-grossing event in which hedge funds are unwinding their leverage by selling stocks.
Lee observed that the Cboe Volatility Index - or VIX, frequently called the stock market's fear gauge - has closely followed the price of GameStop shares since mid January, "when GameStop went mental," according to the note.
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Lee explained that GameStop could still be a popular short among hedge funds, and a surging price in the video game retailer's share price means quant funds require short-covering.
"Going long the VIX is not a bad proxy, and a rising VIX causes value-at-risk models to require hedge funds to de-gross, or reduce leverage," Lee said.
The GameStop surge could lead to a surge in the VIX, which could then result in hedge funds de-grossing their portfolios, leading to stocks falling, the note said.
"It is not surprising to see GameStop create another wave of panic and post-traumatic de-gross," Lee said.
He added: "This is merely an observation and may not be the actual mechanism."
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But since economic momentum is strengthening, volatility surges represent "temporary equity headwinds," according to Lee. Instead of signalling new lows ahead, Lee views the spike in market volatility as a "rotational" event based on cautious (not ebullient) client conversations and improving economic visibility, the note said.
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