Hamilton also met Weinstock and the Lego designer who helped usher the kit toward production.
After Lego produced its first kits, Hamilton got a first look at herself as a plastic figurine.
Hamilton, who is now 81 years old, led the development of flight software for the Apollo moon missions.
Finally, the set will include a circa-1959 Margaret Hamilton, who's a computer scientist and entrepreneur.
Roman is often called the "Mother of Hubble" for helping get the space telescope mission off the ground.
Astronomer and teacher Nancy Grace Roman, who is 92 years old today, is molded as her 1959 likeness.
The space shuttle even separates into its three stages: the solid rocket boosters (left), main fuel tank (orange), and orbiter (right).
Both astronauts will have a mini-space shuttle to stand by.
Astronaut Mae Jemison, a physician and engineer, wears a 1992-era space shuttle flight suit.
Astronaut, physicist, and entrepreneur Sally Ride will come in a 1983-era training flight suit.
Each set will come with 231 pieces and some brand-new parts.
The four figurines are molded in the likenesses of the woman they represent.
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