Holland's interviewer, Oliver Franklin-Wallis, wrote in his GQ cover story that China was the final stop of the tour.
"I was really ill," Holland said. "But I didn't say no. I was like, 'I can do it, I can do it, I can do it.'"
Franklin-Wallis wrote that Holland's body finally pushed back against the constant work during a press conference and the actor "walked off the stage and threw up everywhere."
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"I was under a lot of pressure to finish the day's work," Holland recalled. "That was the first time I was really like, 'No, I'm done now. I've given you everything.'"
Holland's role as Spider-Man in the MCU is his biggest part to date.
The British actor got his start in the entertainment industry as a child, when he landed a role as the titular character in "Billy Elliot the Musical" in London's West End. He made his debut in September 2008 and starred in his first film, "The Impossible," four years later.
When Holland was announced as the latest Spider-Man actor in June 2015, after seven auditions and a screen test with Robert Downey Jr., he was 19 years old and relatively unknown in Hollywood.
Holland's MCU debut in 2016's "Captain America: Civil War" caused his popularity to skyrocket and he became a global star the following year when his first standalone "Spider-Man" movie, "Homecoming," was released.
Holland will return in "Spider-Man: No Way Home," which is set for release on December 17. The actor has repeatedly said that the film is his last in his current contract, so his future in the MCU beyond that is unclear.
In his GQ cover story, the star said that one of his "biggest faults" is that he's "an impossible people pleaser."
Because of this, he said that he often works himself to the point of exhaustion on his projects.
For his role as an Army veteran and drug addict in "Cherry," Holland lost and gained 30 pounds, which resulted in low energy levels.
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He also dislocated his ankle while running for a war scene that occurred during the last two weeks of filming "Cherry." He almost broke his ankle and nose on the film, too. Holland broke his nose while filming the two movies "The Lost City of Z" and "Chaos Walking."
"She gave me an amazing piece of advice: 'No' is a full sentence. 'No' is enough,'' Holland said.
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